Tier 3, Preclinical only
Evidence is limited to animal or in-vitro work. No human pharmacokinetics. Any human dose in circulation is extrapolated, and extrapolation across species routinely fails.
Half-life
Not established
No validated pharmacokinetic half-life located in an allowed primary source. 16-amino-acid peptide encoded in the mitochondrial 12S rRNA region.
Dosing
No established dose
No established human dose. Animal studies use body-weight-based intraperitoneal/subcutaneous dosing (mg/kg); not standardized. Kept qualitative per instructions.
Regulatory status
Not approved. Preclinical/experimental mitochondrial-derived peptide.
Evidence base
animal only · confidence: low
Rodent metabolic/exercise studies and mechanistic work; no controlled human efficacy or PK data in allowed sources.
Safety
No human safety data. Preclinical only; safety in humans unestablished. Not for clinical dosing decisions.