Half-life studio
A dose is only half the question. How often you take it decides whether levels hold steady, swing wildly, or clear entirely between injections. Only compounds with a half-life traceable to a real source appear here.
Levels build to 2.00x a single dose and swing 2.0x between peak and trough, a relatively steady profile for this half-life.
Half-life source and model assumptions
Half-life used: 7.0 days · human data · subcutaneous
Approximately 1 week. Long half-life is driven by albumin binding, which slows renal clearance and protects against DPP-4 degradation. Present in circulation for ~5 weeks after the last dose.
This is a one-compartment model with first-order elimination, shown in multiples of a single dose rather than absolute blood levels, the volume of distribution is unknown for most of these compounds, so any absolute concentration would be invented. Ratios, accumulation, and time-to-plateau do not depend on it. Real pharmacokinetics vary between people; this describes the shape of a curve, not what will happen in your body.