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Dalargin

Neuropeptide

Also known as: Dalargine, Tyr-D-Ala-Gly-Phe-Leu-Arg

Tier 2, Investigational, human data

Studied in registered human trials with published pharmacokinetic data, but not approved. Dosing outside a trial protocol has no established safety margin.

Half-life
Not established

A rat PK study (Kalenikova et al., Vopr Med Khim 1988, PMID 3369130) describes the plasma curve as a three-exponential function after IV 3H-dalargin but the accessible English abstract states no numeric half-life. The commonly repeated ~35 min figure appears only on vendor sites and could not be verified, so it is NOT recorded.

Dosing
No established dose

No standardized mcg dosing regimen found on allowed hosts. Russian/Ukrainian clinical literature describes injection, endonasal electrophoresis, and ultraphonophoresis routes for GI/skin indications, but exact per-dose amounts were not extractable from the fetched abstracts.

Regulatory status
Registered and clinically used as a prescription drug in Russia/Ukraine and other former-Soviet states (e.g., peptic ulcer, pancreatitis). NOT approved by FDA or EMA; no Western regulatory approval exists.
Evidence base
human clinical · confidence: low

Almost entirely Russian/Ukrainian-lineage literature (1980s-2000s), often without English full text or modern replication. No Western double-blind RCTs found. Clinical-use citations are small regional studies. Sequence and MW 725.8 Da confirmed on PubChem (CID 6917894).

Safety

Human clinical use is documented only in regional (Russian/Ukrainian) literature, largely for GI indications, not for research/performance/self-administration contexts. No Western pharmacovigilance, no FDA/EMA safety review. Absence of reported harm in older regional literature is not evidence of safety in other populations, doses, or routes.