BPC-157
Tissue repair peptide
Also known as: Body Protection Compound 157, Pentadecapeptide BPC 157, PL 14736
Evidence is limited to animal or in-vitro work. No human pharmacokinetics. Any human dose in circulation is extrapolated, and extrapolation across species routinely fails.
NO ESTABLISHED HUMAN HALF-LIFE. Elimination half-life is under 30 minutes in rats and beagle dogs, with linear kinetics and intramuscular bioavailability of ~14-19% (rats) and ~45-51% (dogs). The only human characterization is a 2-subject intravenous pilot in which plasma levels returned to baseline within 24 hours. Cross-species extrapolation of peptide pharmacokinetics is unreliable, so no human figure is presented here. Any specific human half-life you see quoted elsewhere is not sourced from human data.
NO ESTABLISHED HUMAN DOSE. Dosing figures circulating online (commonly cited as 200-500 mcg daily) trace to community convention, not to published human dose-finding studies. They are presented nowhere in this app as a recommendation because no defensible source exists.
Large volume of rodent literature, much of it from a single research group in Zagreb, with limited independent replication. Human evidence is limited to small pilot studies. Positive animal findings across an unusually broad range of unrelated conditions is itself a reason for caution rather than confidence.
Lyophilised: Peptides are generally stored frozen or refrigerated and protected from light; no product-specific label exists.
Reconstituted: No manufacturer stability data exists, there is no approved product to have a label.
Human safety is not established. There are no adequate human trials, no approved manufacturing standard, and therefore no assurance of identity, purity, or sterility in material sold as BPC-157. The FDA flagged it for significant safety risks in the 503A bulk substances review. Absence of reported harm is not evidence of safety when systematic human study has not been done.
- Pharmacokinetics, distribution, metabolism, and excretion of body-protective compound 157 in rats and dogs · pubmed
- Multifunctionality and Possible Medical Application of the BPC 157 Peptide, Literature and Patent Review · pubmed
- PCO-02, Safety and Pharmacokinetics Trial (ClinicalTrials.gov NCT02637284) · other